Topical photodynamic therapy induces systemic immunosuppression via generation of platelet-activating factor receptor ligands
نویسندگان
چکیده
Matheus Ferracini1, Ravi P. Sahu2,3, Kathleen A. Harrison5, Robert A. Waeiss4, Robert C. Murphy5, Sonia Jancar1, Raymond L. Konger2,3, and Jeffrey B. Travers2,4,6,7 1Department of Immunology, Biomedical Sciences Institute, University of Sao Paulo, Brazil 2Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202 3Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202
منابع مشابه
Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species.
Recent studies have implicated the lipid mediator platelet-activating factor (PAF) in UVB-mediated systemic immunosuppression known to be a major cause for skin cancers. Previously, our group has demonstrated that UVB irradiation triggers the production of PAF and oxidized glycerophosphocholines that act as PAF-receptor (PAF-R) agonists. The present studies explored the mechanisms by which UVB ...
متن کاملSystemic Chemotherapy Is Modulated by Platelet-Activating Factor-Receptor Agonists
Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms. Previous studies have demonstrated that prooxidative stressor-mediated generation of oxidized lipids with platelet-activating factor-receptor (PAF-R) agonistic activity induces systemic immunosuppression that augments the growth of experimen...
متن کاملHypericin-photodynamic therapy inhibits proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes cell line MH7A
Objective(s): To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen spec...
متن کاملP 143: The Effect of Platelet Activating Factor on Inflammatory Response in Multiple Sclerosis
Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...
متن کاملLi Therapy for acute pancreatitis with platelet - activating
Acute pancreatitis (AP) causes release of plateletactivating factor (PAF), which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF is a cell surface secretion of bioactive lipid, which could produce physiological and pathological effects by binding to its cell surface receptor called platelet-activating factor receptor (PAF-R). Studies showed t...
متن کامل